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human umbilical cord-derived mesenchymal stem cells (Children's Hospital of Fudan University)
- Development stage
- Unknown
- Lead developer
- Children's Hospital of Fudan University
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intratracheal
01
Overview
This investigational cell therapy consists of allogeneic human umbilical cord-derived mesenchymal stem cells (UC-MSCs) developed by the Children's Hospital of Fudan University for the treatment of bronchopulmonary dysplasia (BPD) in extremely preterm infants. Administered via the intratracheal route, the therapy utilizes the regenerative and immunomodulatory properties of MSCs to address the underlying pathology of BPD, which is characterized by impaired alveolarization and chronic lung inflammation. The mechanism of action involves the cells' ability to modulate the inflammatory environment in the neonatal lung, promote tissue repair through paracrine signaling, and support the development of alveolar structures. A multi-center Phase 1/2 clinical trial (NCT03645525) has been conducted to evaluate the safety and efficacy of these cells in infants at high risk for developing BPD.
- Other names
- UC-MSCshUC-MSCsUmbilical Cord-derived Mesenchymal Stem CellIntratracheal Umbilical Cord-derived Mesenchymal Stem Cell
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