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human umbilical cord-derived mesenchymal stem cells (Guangzhou Women and Children's Medical Center)
- Development stage
- Unknown
- Lead developer
- Guangzhou Women and Children’s Medical Center
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
Human umbilical cord-derived mesenchymal stem cells (hUC-MSC) is a cell therapy being developed by Guangzhou Women and Children's Medical Center for the treatment of Alport syndrome, a hereditary renal disease. These cells are characterized by their anti-inflammatory and anti-fibrotic properties, which aim to ameliorate renal injury and prevent podocyte apoptosis. In clinical trials involving children with early-stage Alport syndrome and chronic kidney disease (CKD) stages I-III, the therapy is administered via peripheral intravenous infusion to evaluate its safety and efficacy in slowing disease progression toward end-stage renal disease. Preclinical studies have demonstrated that hUC-MSC treatment can extend survival and reduce renal damage in Alport syndrome models.
- Other names
- human umbilical cord mesenchymal stem cellshUC-MSCs
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