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human umbilical cord mesenchymal stem cell-derived exosomes + human bone marrow mesenchymal stem cell-derived exosomes
- Development stage
- Unknown
- Lead developer
- Ngô Anh Tuấn
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Cell Therapies
- Administration
- Topical
01
Overview
This combination biologic therapy consists of exosomes harvested from human umbilical cord mesenchymal stem cells (UC-MSCs) and human bone marrow mesenchymal stem cells (BM-MSCs). These exosomes are extracellular vesicles that carry a cargo of proteins, lipids, and nucleic acids capable of modulating the microenvironment of damaged tissue. In clinical applications for atrophic acne scars, the exosomes are applied topically as an adjunct to ablative fractional CO2 laser treatment. The mechanism involves the promotion of wound healing, reduction of post-laser inflammation, and stimulation of collagen remodeling to improve skin texture and scar depth. The development is currently being evaluated in a randomized controlled trial led by Ngô Anh Tuấn.
- Other names
- UC-MSC-derived exosomes + BM-MSC-derived exosomesExosomes derived from human umbilical cord and bone marrow mesenchymal stem cellsexosomes derived from human umbilical cord mesenchymal stem cells + exosomes derived from human bone marrow mesenchymal stem cells-Ngô Anh Tuấn-atrophic acne scars
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