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huzhangxiefei decoction (Xinhua Hospital)
- Development stage
- Unknown
- Lead developer
- Xinhua Hospital
- Administration
- Oral
01
Overview
Huzhangxiefei Decoction is a Traditional Chinese Medicine (TCM) herbal formula being investigated for the treatment of sepsis-induced acute lung injury (ALI). Developed by researchers at Xinhua Hospital, affiliated with the Shanghai Jiao Tong University School of Medicine, the decoction is administered orally or via nasogastric tube. It is hypothesized to attenuate systemic organ failure and lung injury by modulating inflammatory biomarkers (such as C-reactive protein and procalcitonin), reducing vascular and alveolar epithelial injury, and promoting a fibrinolytic state. The formula likely contains *Polygonum cuspidatum* (Huzhang) as a primary ingredient, which is known for its anti-inflammatory and antioxidant properties. Clinical evaluation focuses on its ability to improve respiratory rates, oxygenation indices, and chest X-ray scores in patients with sepsis.
- Other names
- Huzhangxiefei DecoctionHuzhang Xiefei Decoction
02
Targets
ANGPT2 (Angiopoietin-2)AGER (RAGE)THBD (Thrombomodulin)TFPI (Tissue factor pathway inhibitor)
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