Drug intelligence / Profile preview

hyaluronic acid + botulinum toxin type A

Development stage
Unknown
Lead developer
AbbVie
Modality
Recombinant Proteins and Enzymes
Administration
Intradermal, Intramuscular
01

Overview

A combination of **hyaluronic acid** (a glycosaminoglycan used as a dermal filler for soft tissue augmentation) and **botulinum toxin type A** (a neurotoxin protein that inhibits acetylcholine release at neuromuscular junctions), delivered together via injection for aesthetic and dermatological purposes, primarily **facial rejuvenation** (wrinkle reduction, skin texture and pore improvement). The combination leverages the muscle-relaxing action of botulinum toxin type A, which temporarily reduces dynamic wrinkles by blocking neuromuscular transmission, and the hydrating, volumizing, and skin-structural benefits of hyaluronic acid, which fills static wrinkles and restores facial volume. Studies consistently report **greater efficacy, longer duration of effect, smaller toxin doses, and improved patient satisfaction** compared to the use of either agent alone. The treatment is widely used in aesthetic medicine for facial rejuvenation, wrinkle reduction, and for improving acne-associated enlarged pores[1][2][3][4].

Other names
hyaluronic acid and botulinum toxin type Ahyaluronic acid plus botulinum toxin type A
02

Targets

α3β2 nAChR (α3β2 nicotinic receptor)SNAP25 (Synaptosome-associated protein 25)Muscle-type nicotinic acetylcholine receptor

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