Drug intelligence / Profile preview

hyaluronic acid + triamcinolone acetonide

Development stage
Phase 3
Lead developer
KalVista Pharmaceuticals
Modality
Small Molecules
Administration
Intraarticular
01

Overview

**Hyaluronic acid + triamcinolone acetonide** is a combination drug designed for *intra-articular injection* for the treatment of musculoskeletal disorders, especially osteoarthritis. **Hyaluronic acid** is a polysaccharide that acts as a lubricant and shock absorber within joint spaces, improving joint function and reducing pain. **Triamcinolone acetonide** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive activity. In combination, these agents aim to simultaneously replenish joint lubrication and suppress local inflammation to relieve pain and improve mobility[5][3]. Studies indicate that such combinations may offer improved and sustained symptomatic relief compared to hyaluronic acid alone, though prolonged use or high doses may increase risk of cartilage damage[3]. Primary indications include osteoarthritis (particularly of the knee), but combinations may be researched or used for other joint inflammatory disorders.

Brand names
HydrosHydros-TA
Other names
hyaluronic acid + triamcinolonetriamcinolone acetonide + hyaluronic acidtriamcinolone/hyaluronic acid
02

Targets

GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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