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hyaluronic acid + triamcinolone hexacetonide
- Development stage
- Unknown
- Lead developer
- Anika Therapeutics
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Intraarticular
01
Overview
This combination therapy for knee osteoarthritis involves the intra-articular injection of hyaluronic acid (specifically the brand Osteonil) and the corticosteroid triamcinolone hexacetonide. Hyaluronic acid acts as a viscosupplement, restoring the viscoelastic properties of synovial fluid to provide lubrication and shock absorption. Triamcinolone hexacetonide is a potent anti-inflammatory corticosteroid that provides rapid pain relief. The University of Sao Paulo General Hospital conducted a Phase 4 study (NCT01813565) to determine the optimal dosing regimen (single vs. multiple injections) for this combination, aiming to improve clinical outcomes as measured by VAS, WOMAC, and Lequesne scores.
- Brand names
- Osteonil
- Other names
- viscosupplementation 1+1+1viscosupplementation 3 at onceviscosupplementation3 at onceviscosupplementation-3 at onceviscosupplementation-University of Sao Paulo General Hospital-knee osteoarthritis
02
Targets
GR (Glucocorticoid receptor)CD44 (CD44 antigen)
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