Drug intelligence / Profile preview

hyaluronic acid + vitamin C

Development stage
Unknown
Lead developer
Kiehl's
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Hyaluronic acid + vitamin C is a combination of two active ingredients commonly used in dietary supplements and topical skincare products. Hyaluronic acid is a naturally occurring glycosaminoglycan that acts as a humectant, binding water to retain skin moisture and promote plumpness. Vitamin C (ascorbic acid) is a potent antioxidant that protects the skin from oxidative stress, supports collagen synthesis, brightens pigmentation, and helps repair photodamage. When combined, these ingredients provide synergistic benefits for skin health—hyaluronic acid hydrates and plumps the skin while vitamin C protects against free radicals and boosts collagen production. This combination is widely used to address signs of aging such as fine lines, wrinkles, uneven tone, dryness, and loss of elasticity[2][5][6]. Clinical studies suggest beneficial effects on dermis density and texture; however, evidence for superior efficacy over single-ingredient formulations remains limited[1].

Other names
sodium hyaluronate + ascorbic acidhyaluronic acid + vitamin c
02

Targets

PHD1 (Prolyl hydroxylase domain-containing protein 1)LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1)CD44 (CD44 antigen)RHAMM (Hyaluronan-mediated motility receptor)LH (Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1)

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