Drug intelligence / Profile preview

hydrochlorothiazide + triamterene

Development stage
Approved
Lead developer
GSK
Modality
Small Molecules
Administration
Oral
01

Overview

Hydrochlorothiazide + triamterene is a fixed-dose combination medication consisting of two diuretics used to treat high blood pressure (hypertension) and edema (fluid retention). Hydrochlorothiazide is a thiazide diuretic that works by increasing the excretion of sodium and water from the kidneys, thereby lowering blood pressure. Triamterene is a potassium-sparing diuretic that helps prevent excessive loss of potassium caused by hydrochlorothiazide. This combination is particularly indicated for patients at risk of hypokalemia (low potassium levels) or those who have developed hypokalemia on thiazides alone. The drug acts primarily through renal mechanisms to promote natriuresis while maintaining potassium balance[1][4][8].

Brand names
DyazideMaxzideMaxzide-25Maxzide25Maxzide 25
Other names
co-triamterzide
02

Targets

ENaCSLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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