hydrocodone + acetaminophen + promethazine

This immediate-release combination drug contains **hydrocodone** (a semi-synthetic opioid agonist for pain relief), **acetaminophen** (a non-opioid analgesic and antipyretic), and **promethazine** (a first-generation antihistamine with antiemetic, sedative, and anti-allergic properties). Hydrocodone acts as a mu-opioid receptor agonist to reduce pain perception, acetaminophen provides analgesia and fever reduction via central mechanisms, and promethazine, an H1 histamine receptor antagonist, reduces nausea (notably opioid-induced nausea/vomiting), provides additional mild sedation, and may reduce allergic responses. This combination (marketed as Hydexor) was developed specifically for the **short-term management of acute pain** that requires an opioid, particularly in patients prone to opioid-induced nausea and vomiting, with the goal of addressing both pain and opioid-related side effects[2].

Brand names

Hydexor

Other names

hydrocodone acetaminophen promethazine