Drug intelligence / Profile preview

hydrocodone bitartrate + acetaminophen

Development stage
Approved
Modality
Small Molecules
Administration
Oral
01

Overview

Hydrocodone bitartrate + acetaminophen is a fixed-dose combination oral analgesic used to treat moderate to severe pain when alternative treatments are inadequate. Hydrocodone is a semi-synthetic opioid analgesic that acts as a full agonist at the mu-opioid receptor in the central nervous system, providing pain relief and cough suppression. Acetaminophen (paracetamol) is an analgesic and antipyretic agent; its precise mechanism of action remains unclear but likely involves inhibition of prostaglandin synthesis in the CNS. The combination leverages both opioid and non-opioid mechanisms for synergistic pain control. Hydrocodone/acetaminophen was first approved in 1982 in the United States and remains one of the most commonly prescribed opioids for acute pain management[1][2][5][7].

Brand names
AnexsiaCeta PlusCo-GesicDolorex ForteHycetLorcetLortabMaxidoneNorcoStagesicVicodin HPZydoneAllayAzdoneBancap HCHyphen
Other names
hydrocodone/acetaminophenhydrocodone/paracetamol
02

Targets

MOR (Mu opioid receptor)COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)

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