Drug intelligence / Profile preview

hydrocortisone + cinchocaine

Development stage
Unknown
Lead developer
Sanofi
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical, Rectal
01

Overview

Hydrocortisone + cinchocaine is a combination topical medication containing hydrocortisone (a synthetic glucocorticoid corticosteroid) and cinchocaine hydrochloride (a local anesthetic). Hydrocortisone reduces inflammation, redness, and swelling by inhibiting the release of inflammatory mediators. Cinchocaine hydrochloride blocks sodium channels in nerve cells, preventing pain signal transmission and providing rapid, prolonged local anesthesia. The combination is primarily used for short-term treatment of hemorrhoids and anal fissures, providing relief from pain, itching, irritation, and swelling in the anorectal area. Available as both ointment and suppository formulations.

Brand names
Uniroid-HCProctosedylHemolit
Other names
hydrocortisone + cinchocaine hydrochloride
02

Targets

GR (Glucocorticoid receptor)SCN10A (Sodium channel protein type X alpha subunit)CaM (Calmodulin)SCN5A (Sodium channel protein type 5 subunit alpha)

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