Drug intelligence / Profile preview

hydrocortisone + ibuprofen

Development stage
Unknown
Lead developer
Eton Pharmaceuticals
Modality
Small Molecules
Administration
Oral (both Drugs Are Available In Oral Formulations[1])
01

Overview

This is a combination of two drugs: - **Hydrocortisone** (marketed as Alkindi Sprinkle with the imprint "INF-2.0") is a synthetic glucocorticoid used primarily for adrenocortical insufficiency and other conditions requiring corticosteroid therapy. It acts by mimicking endogenous cortisol, exerting anti-inflammatory and immunosuppressive effects through binding to the glucocorticoid receptor. - **Ibuprofen** is a nonsteroidal anti-inflammatory drug (NSAID) widely used for pain relief, fever reduction, and inflammation control. It works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing prostaglandin synthesis. No evidence was found that "INF2.0 + ibuprofen" exists as a marketed fixed-dose combination product; this entry describes the theoretical or compounded use of both agents together.

Brand names
Alkindi Sprinkle (for hydrocortisone)ibuprofen (various brands)
Other names
INF2.0 + ibuprofen
02

Targets

GR (Glucocorticoid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)

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