hydrocortisone acetate + polymyxin b sulfate + neomycin

Hydrocortisone acetate + polymyxin b sulfate + neomycin is a long-established **topical anti-inflammatory and antibacterial combination drug** composed of the corticosteroid hydrocortisone acetate and the antibiotics neomycin and polymyxin B sulfate. The product is marketed under brands such as Cortisporin and Otosporin and has been used for corticosteroid-responsive dermatoses with secondary bacterial infection, otitis externa, and certain ophthalmic inflammatory conditions with susceptible bacterial involvement, depending on formulation. Hydrocortisone acetate acts as a **glucocorticoid receptor agonist** to suppress local inflammation, pruritus, and erythema, while neomycin inhibits bacterial protein synthesis through binding to the **30S ribosomal subunit** and polymyxin B disrupts the **bacterial outer and cytoplasmic membranes** by interacting with lipopolysaccharide and membrane phospholipids. It is an approved prescription pharmaceutical and a **small molecule combination** product available from multiple manufacturers, including branded and generic versions.

Brand names

CortisporinOtosporinCasporyn HCOticairOtobioneOtocortPediotic

Other names

hydrocortisone acetate + polymyxin b sulfate + neomycinhydrocortisone acetate + neomycin sulfate + polymyxin b sulfate