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hydrocortisone acetate + thonzonium bromide + neomycin sulfate + colistin sulfate
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Otic
01
Overview
Cortisporin-TC Otic Suspension is a combination medication used to treat superficial bacterial infections of the external auditory canal. It contains colistin sulfate and neomycin sulfate as antibacterial agents, hydrocortisone acetate to reduce inflammation, and thonzonium bromide to enhance the penetration of active ingredients by dispersing cellular debris and exudate. **Mechanism of Action**: Colistin sulfate disrupts bacterial cell membranes, neomycin sulfate inhibits protein synthesis, hydrocortisone acetate controls inflammation, and thonzonium bromide aids in tissue contact of the active ingredients[1][2][4].
- Brand names
- Cortisporin-TCColy-Mycin S
- Other names
- Thonzonium bromide, colistin sulfate, neomycin sulfate, hydrocortisone acetate combination
02
Targets
GR (Glucocorticoid receptor)30S A-site (Bacterial ribosomal 30S A-site)
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