Drug intelligence / Profile preview

Hydrocortisone butyrate + Hydrocortisone acetate

Development stage
Unknown
Lead developer
PreCision Dermatology
Modality
Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration
Topical, Rectal
01

Overview

Hydrocortisone butyrate and hydrocortisone acetate are both topical corticosteroids that share similar actions but are different esters of hydrocortisone. They are used separately for various inflammatory skin conditions. Hydrocortisone butyrate is a potent topical corticosteroid used to treat inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. It's available in various formulations including cream, ointment, lotion, and scalp lotion. Hydrocortisone acetate is used for similar purposes and is also administered rectally as suppositories or aerosol foam for conditions like ulcerative colitis, and for oral inflammatory lesions. Both medications work by reducing inflammation, itching, and redness in skin conditions by calming down the immune system's defense cells and stopping them from releasing substances that cause inflammation. They may also narrow blood vessels where applied, which helps reduce swelling. The provided search results do not indicate a specific combination product containing both hydrocortisone butyrate and hydrocortisone acetate together.

02

Targets

GR (Glucocorticoid receptor)

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