Drug intelligence / Profile preview

hydrogen peroxide + sodium fluoride

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Topical (mouth Rinse, Toothpaste)
01

Overview

**Hydrogen peroxide + sodium fluoride** is a combination used primarily in oral care products, notably in mouthrinses and toothpastes, for its dual roles in **oral disinfection, gingivitis reduction, tooth whitening, and caries prevention**. Hydrogen peroxide acts as a strong oxidizing agent, releasing oxygen that helps break down biofilms, kill bacteria (especially anaerobic species), and bleach stains from teeth. Sodium fluoride provides fluoride ions to help remineralize enamel and prevent dental caries. Combined, they are effective at whitening teeth and improving gingival health without negative interactions; fluoride does not inhibit the action or breakdown of hydrogen peroxide. The combination is generally considered safe for oral use at recommended concentrations, and is used for daily oral hygiene to address gingivitis, plaque, and tooth discoloration[1][2][3][4][6].

Brand names
Listerine Healthy WhiteListerine WhiteningListerine Healthy White VibrantListerine Healthy White Restoring
Other names
Hydrogen Peroxide/Sodium Fluoride Mouth RinseExperimental Mouth Rinse (NCT01838330)

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