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hydroxychloroquine + clindamycin
- Development stage
- Preclinical
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A combination of hydroxychloroquine, an antimalarial and immunomodulatory agent, with clindamycin, an antibiotic effective against anaerobic bacteria and various gram-positive organisms. This combination has shown enhanced efficacy in treating malaria by improving parasite clearance and therapeutic response compared to monotherapy. The combination requires careful monitoring due to potential cardiovascular risks and drug interactions.
02
Targets
Bacterial 50S ribosomal subunitFe2+-heme in digestive vacuoleACE2 (Angiotensin-converting enzyme 2)
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