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hydroxycitrate + medium-chain triglycerides

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination dietary supplement containing hydroxycitrate (commonly in the form of (-)-hydroxycitric acid, HCA) and medium-chain triglycerides (MCTs). Hydroxycitrate is derived from Garcinia cambogia and is proposed to inhibit ATP citrate lyase, an enzyme involved in de novo lipogenesis, potentially reducing fat synthesis. Medium-chain triglycerides are fats that are more rapidly absorbed and metabolized than long-chain triglycerides, providing a quick energy source and possibly promoting increased fat oxidation. The combination has been studied for effects on satiety, energy intake, weight loss, and metabolic health. Clinical studies indicate that short-term supplementation with this combination may result in modest weight loss but does not significantly increase satiety or reduce energy intake compared to placebo[1][5]. Both components are widely used as dietary supplements rather than pharmaceuticals.

Other names
hydroxycitric acid + medium-chain triglyceridesHCA + MCT
02

Targets

ACLY (ATP-citrate synthase)

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