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hydroxyethyl starch + succinylated gelatin
- Development stage
- Unknown
- Lead developer
- B. Braun
- Modality
- Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Recombinant Proteins and Enzymes, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
hes + Gelofusine refers to the combined or comparative use of hydroxyethyl starch (HES) and succinylated gelatin (Gelofusine), two synthetic colloid solutions used for fluid resuscitation and volume expansion. Hydroxyethyl starch is a polysaccharide derived from amylopectin, typically used in concentrations like 6% (e.g., HES 130/0.4). Gelofusine is a 4% solution of succinylated gelatin, a modified bovine collagen. These agents are primarily administered intravenously to maintain oncotic pressure and intravascular volume during major surgeries, such as liver transplantation, or in critical care settings. Their use is often scrutinized regarding their effects on renal function and coagulation, particularly in patients with pre-existing renal impairment.
- Brand names
- VoluvenTetraspanVenofundin
- Other names
- hes + Gelofusine6% HES 130/0.4 + 4% GelofusineHydroxyethyl starch + Gelatin
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