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hydroxymethylbutyrate + glutamine
- Development stage
- Unknown
- Lead developer
- Hospital General de México \"Dr. Eduardo Liceaga\"
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Hydroxymethylbutyrate + glutamine is a nutritional combination therapy investigated by the Hospital General de Mexico for its potential to enhance wound healing, particularly in patients with type 2 diabetes. Beta-hydroxy-beta-methylbutyrate (HMB) is a metabolite of the amino acid leucine that acts by decreasing muscle protein breakdown (proteolysis) and stimulating protein synthesis. Glutamine is a conditionally essential amino acid that serves as a fuel source for rapidly dividing cells, such as lymphocytes and enterocytes, and is crucial for collagen synthesis during wound repair. Together, this combination aims to improve tissue regeneration by decreasing apoptosis and increasing cell proliferation in bloody areas or chronic wounds.
- Other names
- HMB + glutaminebeta-hydroxy-beta-methylbutyrate + glutamine
02
Targets
mTOR (Mammalian target of rapamycin kinase)
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