hydroxypropyl-guar + polyethylene glycol 400 + propylene glycol

This is a combination ophthalmic formulation containing hydroxypropyl guar, polyethylene glycol 400, and propylene glycol. It is primarily used as a lubricant eye drop for the management of dry eye disease. Polyethylene glycol 400 and propylene glycol act as demulcents (lubricants) that mimic natural tears to provide temporary relief from burning and discomfort due to dryness of the eye. Hydroxypropyl guar serves as a gelling agent that forms a soft, thin gel matrix in situ when exposed to the tear film, prolonging retention time on the ocular surface and enhancing mucous layer thickness[1][3][5]. This combination provides long-lasting relief from dry eye symptoms by stabilizing the tear film, improving ocular surface protection, and reducing evaporation[1][3][5]. The product is available over-the-counter.

Brand names

Systane Lubricant

Other names

PEG/PG/HP-guarpolyethylene glycol 400 and propylene glycol with hydroxypropyl guar