hydroxypyridinone + coumarin

hydroxypyridinone + coumarin is a combination of two small molecules—hydroxypyridinone and coumarin—designed as a hybrid compound displaying multi-target pharmacological activities. Research indicates that these hybrids possess **iron ion chelating activity** and act as **inhibitors of monoamine oxidase B (MAO-B)**, making them promising candidates in neurodegenerative diseases like Alzheimer's disease[1]. Select compounds from this class, notably "compound 27a", have shown substantial iron chelation, inhibited MAO-B with nanomolar potency, protected neuronal cells, and improved cognitive impairment in animal models[1]. Other studies show that the combination also exhibits **antiproliferative effects against hepatocellular carcinoma (HCC) cells**, where it induces autophagy and reduces proliferation through ERK1/2 activation and Akt pathway downregulation[4].

Other names

hydroxypyridinone-coumarinHPC