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hydroxyurea + azathioprine + alemtuzumab + thioptepa + low dose total body irradiation + sirolimus
- Development stage
- Unknown
- Lead developer
- Vrije University Medical Center
- Modality
- Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Oral, Intravenous, External Beam Radiation
01
Overview
A combination immunosuppressive regimen that includes multiple drugs and radiation therapy. The regimen contains hydroxyurea (an antimetabolite), azathioprine (an immunosuppressant), alemtuzumab (a monoclonal antibody), thioptepa (an alkylating agent), low dose total body irradiation (a radiation therapy), and sirolimus (an mTOR inhibitor immunosuppressant). This combination likely provides potent immunosuppression through multiple mechanisms for preventing organ rejection or treating specific conditions.
02
Targets
FKBP1ARNR (Ribonucleotide reductase)Mechanistic target of rapamycin complex 1DNA
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