hydroxyzine + paracetamol

Atarax-P is a combination medication consisting of **hydroxyzine**, a first-generation antihistamine, and **paracetamol** (acetaminophen), an analgesic and antipyretic. It is primarily utilized as a premedication regimen for patients undergoing therapy with monoclonal antibodies, most notably **rituximab**, to prevent or mitigate infusion-related reactions (IRRs). Hydroxyzine acts as an inverse agonist at the **histamine H1 receptor**, providing antiallergic, sedative, and antiemetic effects that counteract the release of inflammatory mediators during infusion. Paracetamol provides antipyretic and analgesic support by inhibiting cyclooxygenase enzymes in the central nervous system, thereby reducing the incidence of fever and chills. This combination is a standard component of safety protocols in oncology and rheumatology to improve patient tolerability during complex biologic administrations.

Brand names

Atarax-P

Other names

hydroxyzine and paracetamolhydroxyzine and acetaminophen