hylan G-F 20 + corticosteroid

This combination treatment protocol involves the intra-articular injection of **hylan G-F 20** (Synvisc) and a **corticosteroid** for the management of knee osteoarthritis. Hylan G-F 20 is a high-molecular-weight, cross-linked hyaluronan derivative that acts as a viscosupplement to restore the rheological properties of synovial fluid, providing lubrication and shock absorption. The addition of a corticosteroid is intended to provide rapid anti-inflammatory relief, potentially addressing the variable symptom improvement often seen in the first 12 weeks following viscosupplementation alone. This specific protocol was evaluated in clinical trials led by the **Steadman Hawkins Research Foundation** to determine if the combination provides superior early-stage outcomes compared to viscosupplementation alone.

Brand names

Synvisc

Other names

Hylan F-20Hylan G-F 20Synvisc + corticosteroidSynvisc + steroid