Drug intelligence / Profile preview

hyoscine + ibuprofen

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Hyoscine + ibuprofen is a fixed-dose combination medication containing two active ingredients: - **Hyoscine butylbromide** (also known as scopolamine butylbromide), an antispasmodic and anticholinergic agent that relieves smooth muscle spasms in the gastrointestinal, biliary, and genitourinary tracts by blocking muscarinic acetylcholine receptors. - **Ibuprofen**, a nonsteroidal anti-inflammatory drug (NSAID) that provides analgesic, anti-inflammatory, and antipyretic effects primarily through inhibition of cyclooxygenase enzymes (COX-1 and COX-2), leading to reduced synthesis of prostaglandins involved in pain and inflammation. This combination is designed to provide both spasmolytic relief from smooth muscle cramps (via hyoscine) and direct pain relief/anti-inflammation (via ibuprofen). It has been developed for symptomatic treatment of conditions such as abdominal cramping, dysmenorrhea (menstrual pain), renal colic, biliary tract spasm, ureteral colic, and other types of visceral pain where both muscle spasm and inflammation contribute to symptoms. The synergistic effect aims for faster onset and greater overall symptom control compared to monotherapy with either agent[1][4][5][6].

Other names
hyoscine butylbromide + ibuprofenscopolamine butylbromide + ibuprofen
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)CHRM3 (M3)

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