hypotonic saline (f2749b)

Hypotonic saline, specifically a 0.65% sodium chloride solution, is an intravenous hydration fluid used in clinical settings. In the context of the PANTER trial (NCT02311231) led by St. Antonius Hospital, it was evaluated as a prophylactic hydration strategy to prevent contrast-induced nephropathy (CIN) in high-risk patients, such as those with chronic kidney disease undergoing transcatheter aortic valve implantation (TAVI). The treatment aims to reduce the risk of acute kidney injury by expanding intravascular volume, which maintains renal blood flow and promotes the diuresis of iodinated contrast media, thereby minimizing direct toxic effects on renal tubules.

Other names

0.65% sodium chloridehypotone saline0.65% NaCl