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i-PRF + FDBA
- Development stage
- Unknown
- Modality
- Tissue Cells → Other Cell Types → Cell Therapies
- Administration
- Surgical Implantation, Intralesional
01
Overview
i-PRF + FDBA is a combination biomaterial therapy used primarily in oral and maxillofacial surgery for bone regeneration and ridge preservation. It consists of injectable platelet-rich fibrin (i-PRF), an autologous blood-derived product rich in platelets, leukocytes, growth factors, and plasma proteins, combined with freeze-dried bone allograft (FDBA), which serves as an osteoconductive scaffold. The mechanism of action involves the sustained release of growth factors from i-PRF to promote angiogenesis, cell migration, proliferation, and differentiation at the graft site while the FDBA provides structural support for new bone formation. This combination enhances early vascularization and osteogenesis compared to either component alone[1][4]. It is not a pharmaceutical drug but rather a regenerative biomaterial approach commonly used in dental implantology and periodontal surgery.
- Other names
- injectable platelet-rich fibrin + freeze-dried bone allografti-PRF plus FDBA
02
Targets
BMPR1AVEGFR2 (Vascular endothelial growth factor receptor 2)PDGFRB (Platelet-derived growth factor receptor beta)
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