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iberdomide + cyclophosphamide + dexamethasone
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Iberdomide + cyclophosphamide + dexamethasone is an investigational, fully oral combination therapy being studied primarily for relapsed or refractory multiple myeloma (RRMM). Iberdomide is a novel cereblon E3 ligase modulator (CELMoD) that binds with high affinity to cereblon, leading to enhanced degradation of transcription factors Ikaros and Aiolos. This results in direct anti-myeloma activity and immune-stimulatory effects, including increased activation of T cells and natural killer (NK) cells. Cyclophosphamide is an alkylating chemotherapy agent with immunomodulatory properties that can potentiate the effects of immunomodulatory drugs. Dexamethasone is a corticosteroid used to reduce inflammation and suppress immune responses, commonly included in myeloma regimens to mitigate side effects and enhance efficacy. The combination has shown promising clinical activity in patients who have received multiple prior lines of therapy[2][6][7][8].
- Other names
- IberCd
02
Targets
GR (Glucocorticoid receptor)CRBN (Cereblon)DNA
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