ibuprofen + chlorphenamine maleate

Ibuprofen + chlorphenamine maleate is a fixed-dose combination small-molecule drug used for the symptomatic relief of the common cold, influenza, and upper respiratory tract infections. It combines ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2) to reduce pain, fever, and inflammation, with chlorphenamine maleate (chlorpheniramine maleate), a first-generation H1 histamine receptor antagonist that relieves symptoms such as runny nose, sneezing, and watery eyes. This combination is marketed under brand names such as Niofen Cold HBP and has been utilized as an active control in clinical trials evaluating natural plant extracts for the common cold.

Brand names

Niofen Cold HBP

Other names

ibuprofen + chlorpheniramine maleateibuprofen and chlorpheniramine maleateibuprofen and chlorphenamine maleate