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ibuprofen + isosorbide dinitrate
- Development stage
- Phase 1
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), and isosorbide dinitrate, a nitric oxide donor. This combination has been studied for the treatment of muscular dystrophies, particularly Duchenne muscular dystrophy. The combination works through complementary mechanisms where isosorbide dinitrate promotes vasodilation and improves blood flow while ibuprofen provides anti-inflammatory effects.
- Other names
- ibuprofen and isosorbide dinitrate combination
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)sGC (Soluble Guanylyl Cyclase)NO2- (Nitrite)
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