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ibuprofen + methyl salicylate + menthol + camphor + eucalyptus oil

Development stage
Unknown
Lead developer
Dr. Sankunni's Ayurvedic Research Foundation
Modality
Small Molecules
Administration
Topical
01

Overview

This is a combination topical analgesic product containing **ibuprofen**, **methyl salicylate**, ****menthol**, **camphor**, and **eucalyptus oil**. The combination is primarily intended for the symptomatic relief of **acute musculoskeletal pain**, including minor aches and pains of muscles and joints associated with backache, arthritis, strains, bruises, and sprains. Each component contributes either anti-inflammatory (ibuprofen), counterirritant, or analgesic properties. **Ibuprofen** is a nonsteroidal anti-inflammatory drug (NSAID) acting mainly via inhibition of cyclooxygenase enzymes, reducing the synthesis of prostaglandins responsible for pain and inflammation[4]. **Methyl salicylate**, **menthol**, and **camphor** are counterirritants that create sensations of coolness or warmth to temporarily mask underlying pain and discomfort[1][3]. **Eucalyptus oil** may provide additional analgesic, anti-inflammatory, or aromatic effects though evidence is largely traditional. The combination does not cure underlying disease but alleviates pain where applied topically[1][3][4].

02

Targets

TRPA1 (Transient receptor potential cation channel subfamily A member 1)PGHS-1 (Prostaglandin G/H Synthase 1)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)TRPV1 (Transient receptor potential cation channel subfamily V member 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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