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Drug intelligence / Profile preview
ibuprofen + narcotic
- Development stage
- Unknown
- Lead developer
- Johnson & Johnson
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Motrin + narcotic is a multimodal analgesic regimen developed by Cape Fear Valley Health System for the management of postoperative pain in adult outpatients. This intervention is not a single fixed-dose combination but a clinical protocol pairing 800 mg of ibuprofen (Motrin), a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes (COX-1 and COX-2), with one of several opioid analgesics, including oxycodone/acetaminophen, hydrocodone/acetaminophen, hydromorphone, or tramadol. The regimen is currently being evaluated in a Phase 4 clinical trial (NCT06495632) to compare the efficacy and feasibility of a fixed-schedule administration versus an as-needed (PRN) approach for moderate-to-severe pain following same-day surgery.
- Other names
- Motrin + narcoticMotrin and narcoticScheduled or As Needed Regimen? a Pilot Feasibility Study on Multimodal Pain Control and Post-Operative Pain
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)
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