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ifosfamide + pegaspargase + gemcitabine + cisplatin + dexamethasone
- Development stage
- Unknown
- Lead developer
- Chinese Academy of Medical Sciences
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous
01
Overview
The IPGDP regimen is a five-drug combination chemotherapy protocol consisting of ifosfamide, pegaspargase, gemcitabine, cisplatin, and dexamethasone. It is being developed and evaluated by the Chinese Academy of Medical Sciences for the treatment of extranodal natural killer/T-cell lymphoma (ENKL), nasal type. This aggressive malignancy is strongly associated with Epstein-Barr virus and often exhibits multidrug resistance. The IPGDP regimen aims to overcome this resistance by combining agents with distinct mechanisms: gemcitabine (a pyrimidine antimetabolite), ifosfamide (an alkylating agent), cisplatin (a platinum-based DNA crosslinker), pegaspargase (an enzyme that depletes L-asparagine), and dexamethasone (a corticosteroid). The regimen is currently in Phase II clinical trials (NCT02560441), where it is being tested in combination with radiotherapy for early-stage disease and as a standalone therapy for advanced or relapsed/refractory ENKL.
- Other names
- IPGDP regimen
02
Targets
DNA polymerase familyRNR (Ribonucleotide reductase)GR (Glucocorticoid receptor)DNA
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