il-18bpa:fc

**il-18bpa:fc** is a recombinant fusion protein combining interleukin-18 binding protein a (IL-18BPa) with the Fc region of immunoglobulin (IgG). IL-18BPa is a naturally occurring protein that binds to and neutralizes interleukin-18 (IL-18), a proinflammatory cytokine involved in the pathogenesis of several inflammatory and autoimmune diseases. By fusing IL-18BPa to the Fc domain, the molecule's half-life in circulation is extended, enhancing its therapeutic potential. The primary mechanism of action is the high-affinity sequestration of IL-18, thereby preventing IL-18 from binding to its receptor and blocking downstream pro-inflammatory signaling such as IFN-γ production[3][5][1]. il-18bpa:fc is being developed for conditions associated with pathological IL-18 activity, such as macrophage activation syndrome (specifically, NLRC4-MAS/XIAP deficiency), adult-onset Still’s disease, and potentially other cytokine-mediated conditions[4][5].

Other names

il-18 binding protein a fc fusionil18 binding protein a fc fusionil 18 binding protein a fc fusionil-18bpa-fcil18bpa-fcil 18bpa-fcil-18bp-fcil18bp-fcil 18bp-fc