Drug intelligence / Profile preview

il-2 + ganciclovir

Development stage
Preclinical
Modality
Cytokines & Interferons → Recombinant Proteins and Enzymes, Small Molecules
Administration
Intravenous, Subcutaneous
01

Overview

This is a combination therapy consisting of interleukin-2 (IL-2) and ganciclovir. Interleukin-2 is a cytokine that stimulates the growth and activity of immune cells, particularly T lymphocytes and natural killer (NK) cells, enhancing the body's immune response against infections and malignancies. Ganciclovir is an antiviral small molecule that inhibits viral DNA polymerase, thereby blocking replication of viruses such as cytomegalovirus (CMV). The combination has been explored in clinical settings for the treatment of AIDS-associated primary central nervous system lymphoma, leveraging IL-2's immunostimulatory effects alongside the antiviral action of ganciclovir[1]. There are potential concerns regarding additive nephrotoxicity when these agents are used together[4].

Other names
il-2 + ganciclovirinterleukin-2 + ganciclovir
02

Targets

IL-2R (Interleukin-2/interleukin-15 receptor complex)DNA polymerase family

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