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IL-2 + IL-12 gene-transfected KB cells
- Development stage
- Preclinical
- Lead developer
- Yokohama City University
- Modality
- Vaccines & Immunotherapeutics, Cell Therapies, Gene Therapies
- Administration
- Intratumoral
01
Overview
**IL-2 + IL-12 gene-transfected KB cells** is an experimental irradiated, gene-modified whole-tumor-cell vaccine evaluated preclinically for head and neck squamous cell carcinoma. It consists of human KB tumor cells separately engineered to express human interleukin-2 and murine interleukin-12, then administered together after irradiation. In a BALB/c nude-mouse KB tumor model, peritumoral administration of the combined cell preparations significantly inhibited established tumor growth, whereas either cytokine-transfected cell preparation alone was not substantially effective. ([jamanetwork.com](https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/483998))
- Other names
- IL-2 + IL-12 gene-transfected KB cellsIL-2 and IL-12 gene-transfected KB cellsIL2 and IL-12 gene-transfected KB cellsIL 2 and IL-12 gene-transfected KB cellsKB/hIL-2 + KB/mIL-12 cellsKB/hIL-2 and KB/mIL-12 cells
02
Targets
IL-12R (Interleukin-12 receptor)IL-2R (Interleukin-2/interleukin-15 receptor complex)
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