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imlifidase + cyclophosphamide + glucocorticoids
- Development stage
- Unknown
- Lead developer
- Hansa Biopharma
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous (imlifidase, Cyclophosphamide), Oral (glucocorticoids, Possibly Cyclophosphamide As Per Protocol Variation)
01
Overview
This is a **combination therapy** comprising imlifidase (a recombinant IgG-degrading enzyme derived from Streptococcus pyogenes), cyclophosphamide (an alkylating agent), and glucocorticoids (synthetic corticosteroids). Imlifidase enzymatically cleaves all human IgG subclasses, providing rapid removal of pathogenic antibodies such as those in anti-GBM (Goodpasture) disease; cyclophosphamide inhibits DNA replication in proliferating lymphocytes, reducing antibody production; glucocorticoids broadly suppress immune and inflammatory responses. The combination is investigated for the treatment of severe **anti-glomerular basement membrane (anti-GBM) antibody disease** (Goodpasture Syndrome), aiming to reverse kidney failure and suppress autoantibody rebound[1][2][3][5][6].
- Other names
- Imlifidase + CYC + glucocorticoids
02
Targets
DNAGR (Glucocorticoid receptor)IgG lower hinge (Immunoglobulin G lower hinge region)
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