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inavolisib + letrozole
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Inavolisib + letrozole is a combination therapy consisting of inavolisib (Itovebi), a potent and selective PI3Kα inhibitor that promotes the degradation of mutated p110α, and letrozole, an aromatase inhibitor. This combination is being investigated for the treatment of PIK3CA-mutated, hormone receptor (HR)-positive, HER2-negative locally advanced or metastatic breast cancer. The combination works by targeting both the PI3K pathway (inavolisib) and estrogen production (letrozole) to inhibit cancer cell growth and proliferation.
- Other names
- inavolisib + letrozole
02
Targets
PIK3CA (Phosphoinositide 3-kinase alpha)CYP19A1 (Aromatase)
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