Drug intelligence / Profile preview

indacaterol + glycopyrronium

Development stage
Phase 4
Lead developer
Novartis
Modality
Small Molecules
Administration
Inhalation
01

Overview

Indacaterol + glycopyrronium is a fixed-dose combination inhaled medication used as a long-term maintenance treatment for airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Indacaterol is an ultra-long-acting beta-2 adrenergic agonist (LABA) that relaxes bronchial smooth muscle to improve airflow. Glycopyrronium is a long-acting muscarinic antagonist (LAMA) that blocks the action of acetylcholine on airway smooth muscle cells, leading to bronchodilation. The combination provides rapid onset of action within 5 minutes and sustained bronchodilation over 24 hours. It is not indicated for asthma or acute relief of symptoms[1][3][5][8].

Brand names
Utibron NeohalerUltibro Breezhaler
Other names
indacaterol and glycopyrrolateindacaterol/glycopyrronium
02

Targets

M1 (Muscarinic acetylcholine receptor M1)CHRM2 (M2)CHRM3 (M3)ADRB2 (β2)

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