Drug intelligence / Profile preview

indium (111In) ion exchange resin

Development stage
Unknown
Lead developer
Mayo Clinic
Modality
Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
Administration
Oral
01

Overview

Indium (111In) radiolabelled ion exchange resin is a diagnostic radiopharmaceutical used in nuclear medicine to evaluate gastrointestinal motility. It typically consists of a cation-exchange resin, such as Amberlite IR-120, which is labeled with the gamma-emitting isotope Indium-111. Because the resin is chemically inert and non-absorbable, it serves as a stable marker for the solid phase of a meal. Following oral administration, the movement of the resin through the stomach, small intestine, and colon is monitored using scintigraphy or SPECT imaging. This allows for the quantitative assessment of gastric emptying, small bowel transit time, and colonic transit, making it a gold-standard tool for diagnosing motility disorders like gastroparesis and chronic constipation.

Other names
111In radiolabelled ion exchange resinIndium-111 ion exchange resinIndium111 ion exchange resinIndium 111 ion exchange resin111In-labeled resin111In-AmberliteIndium-111 Amberlite IR-120Indium111 Amberlite IR-120Indium 111 Amberlite IR-120

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