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indocyanine green + autologous extracellular vesicles
- Development stage
- Unknown
- Lead developer
- Università degli Studi di Milano
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
Indocyanine green + autologous extracellular vesicles (EV-ICG) is an investigational diagnostic imaging agent developed by the **Università degli Studi di Milano**. It consists of the near-infrared fluorescent dye **indocyanine green (ICG)** encapsulated within **autologous extracellular vesicles** (EVs) derived from the patient's own blood or tissue. This formulation is designed to overcome the limitations of free ICG, such as rapid clearance and low tumor specificity. By utilizing the natural tropism of EVs for tumor tissues and the enhanced permeability and retention (EPR) effect, EV-ICG aims to provide superior contrast and prolonged retention within solid neoplasms of the digestive system. The primary clinical application is in **fluorescence-guided surgery**, allowing for the precise intraoperative identification and localization of tumors, including colon, gastric, pancreatic, and neuroendocrine cancers.
- Other names
- ICG-loaded autologous extracellular vesiclesICG-EVsindocyanine green-loaded extracellular vesicles
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