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indocyanine green + neomannosyl human serum albumin
- Development stage
- Unknown
- Lead developer
- Hamamatsu Photonics
- Modality
- Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Recombinant Proteins and Enzymes, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
A macrophage-targeted fluorescent imaging agent composed of **indocyanine green** (ICG), a near-infrared fluorophore, conjugated to **neomannosyl human serum albumin** (MSA), a recombinant human serum albumin modified with neomannose. This combination is developed principally for **sentinel lymph node (SLN) mapping** during oncologic surgery by targeting macrophage mannose receptors, facilitating precise intraoperative visualization with near-infrared fluorescence. The mechanism leverages ICG’s fluorescence, while the neomannosyl modification increases uptake in SLNs by targeting macrophage-rich regions, thus enhancing the signal-to-background ratio[5]. The agent has been studied for potential use in esophageal cancer and aims to overcome limitations of free ICG, such as rapid diffusion and lower selectivity.
- Other names
- indocyanine green-neomannosyl human serum albuminICG-neomannosyl human serum albuminICG:MSA
02
Targets
MRC1 (Mannose Receptor C-type 1)
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