Drug intelligence / Profile preview

indomethacin + celecoxib + esomeprazole

Development stage
Unknown
Lead developer
Merck
Modality
Small Molecules
Administration
Oral, Intravenous, Rectal
01

Overview

This is a combination of three medications: indomethacin (a traditional non-steroidal anti-inflammatory drug or NSAID), celecoxib (a selective COX-2 inhibitor), and esomeprazole (a proton pump inhibitor). While each component has established uses, this specific three-drug combination is not a standard therapeutic regimen documented in clinical practice. Individually: - Indomethacin is an NSAID with anti-inflammatory, analgesic, and antipyretic properties used for conditions like rheumatoid arthritis, osteoarthritis, and gout. - Celecoxib is a selective COX-2 inhibitor used for arthritis with potentially lower gastrointestinal risks than traditional NSAIDs. - Esomeprazole is a proton pump inhibitor that reduces stomach acid production and is often co-prescribed with NSAIDs to protect against gastrointestinal damage.

02

Targets

ATP4A (Potassium–transporting ATPase alpha chain 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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