Drug intelligence / Profile preview

Infanrix Hexa + Bexsero

Development stage
Unknown
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Infanrix Hexa + Bexsero refers to the co-administration of two distinct pediatric vaccines: Infanrix Hexa, a hexavalent vaccine, and Bexsero, a multicomponent serogroup B meningococcal vaccine. Infanrix Hexa provides active immunization against diphtheria, tetanus, pertussis (whooping cough), poliomyelitis, hepatitis B, and invasive diseases caused by Haemophilus influenzae type b (Hib). It contains toxoids, inactivated polioviruses, recombinant hepatitis B surface antigen, and purified pertussis antigens. Bexsero (4CMenB) is designed to prevent invasive meningococcal disease caused by Neisseria meningitidis serogroup B and consists of four main components: factor H binding protein (fHbp), Neisserial adhesin A (NadA), Neisserial heparin-binding antigen (NHBA), and outer membrane vesicles (OMV) containing PorA P1.4. This combination is commonly used in routine infant immunization schedules. Clinical research, including studies sponsored by CHU de Quebec-Universite Laval, has focused on evaluating the safety, reactogenicity, and potential immunological interactions when these vaccines are administered concurrently at the same visit versus separate visits.

Other names
DTaP-IPV-HepB-Hib + Meningococcal group B vaccine4CMenB + Infanrix Hexa
02

Targets

Diphtheria toxinfHbp (Factor H-binding protein)FHA (Filamentous hemagglutinin)HBsAg (Hepatitis B surface antigen)NadA (Neisserial adhesin A)NHBA (Neisserial heparin-binding antigen)PRN (Pertactin)PorA

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