influenza vaccine (surface antigen, inactivated, adjuvanted) (CSL Seqirus)

MF59-adjuvanted inactivated influenza vaccine is a seasonal influenza vaccine specifically designed for older adults (aged 65 and older) to overcome immunosenescence. It contains inactivated influenza virus surface antigens, primarily hemagglutinin (HA), and is formulated with MF59, a squalene-based oil-in-water emulsion adjuvant. The MF59 adjuvant enhances the immune response by creating a local immunostimulatory environment at the injection site, which recruits and activates antigen-presenting cells. This leads to increased production of HA-specific IgG antibodies, enhanced antibody-dependent cellular cytotoxicity (ADCC), and robust polyfunctional CD4+ and CD8+ T cell responses. The vaccine is available in both trivalent (Fluad) and quadrivalent (Fluad Quadrivalent) formulations and is manufactured by Seqirus (a CSL company).

Brand names

FluadFluad QuadrivalentFluad Tetra

Other names

MF 59 adjuvanted inactivated influenza vaccineMF59 adjuvanted inactivated influenza vaccineMF-59 adjuvanted inactivated influenza vaccineMF59-adjuvanted inactivated influenza vaccineMF-59-adjuvanted inactivated influenza vaccineMF 59-adjuvanted inactivated influenza vaccineadjuvanted enhanced inactivated influenza vaccineMF59-adjuvanted trivalent influenza vaccineMF-59-adjuvanted trivalent influenza vaccineMF 59-adjuvanted trivalent influenza vaccineMF59-adjuvanted quadrivalent influenza vaccineMF-59-adjuvanted quadrivalent influenza vaccineMF 59-adjuvanted quadrivalent influenza vaccine