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The influenza virus vaccine for the 2007-2008 Northern Hemisphere season was a trivalent formulation designed to provide protection against the three most prevalent circulating strains of the influenza virus during that period. As recommended by the World Health Organization (WHO) and the FDA's Vaccines and Related Biological Products Advisory Committee (VRBPAC), the formulation included an A/Solomon Islands/3/2006 (H1N1)-like virus, an A/Wisconsin/67/2005 (H3N2)-like virus, and a B/Malaysia/2506/2004-like virus. These vaccines work by inducing neutralizing antibodies against the viral surface glycoproteins, hemagglutinin and neuraminidase, thereby preventing viral entry and release from host cells. Multiple manufacturers produced various forms of the vaccine, including inactivated split-virion, subunit, and live-attenuated intranasal formulations.
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