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INFUSE Bone Graft + INTER FIX
- Development stage
- Unknown
- Lead developer
- Medtronic
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Implantation
01
Overview
INFUSE Bone Graft + INTER FIX is a combination product consisting of a biologic component (recombinant human Bone Morphogenetic Protein-2 [rhBMP-2] applied to an absorbable collagen sponge [ACS]) and a titanium interbody fusion device (INTER FIX). Developed by Medtronic Spinal and Biologics, it is designed for use in spinal fusion procedures, specifically posterior lumbar interbody fusion (PLIF) in patients with degenerative disc disease. The rhBMP-2 acts as an osteoinductive growth factor that binds to bone morphogenetic protein receptors on mesenchymal stem cells and osteoprogenitor cells, stimulating their differentiation into osteoblasts to promote new bone formation. The INTER FIX device provides structural stability and a space for the bone graft to facilitate fusion, eliminating the need for autologous bone graft harvesting from the patient's iliac crest.
- Brand names
- INFUSE Bone GraftINTER FIX
- Other names
- rhBMP-2/ACSrecombinant human Bone Morphogenetic Protein-2 on an Absorbable Collagen Sponge with INTER FIX devicerhBMP-2/ACS/INTER FIX device
02
Targets
BMPR1ABMPR1BBMPR2 (Bone morphogenetic protein receptor type II)
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