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inosine + tocopherol + tocotrienol + coenzyme Q10 + niacinamide + vitamin C + N-acetyl cysteine + multivitamin + minocycline
- Development stage
- Unknown
- Lead developer
- Mid-Atlantic Retina Consultations
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination therapy is a multi-ingredient nutritional and pharmaceutical regimen investigated as an adjunctive treatment for diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD). Developed by Mid-Atlantic Retina Consultations, Inc., the cocktail combines the tetracycline antibiotic minocycline with a specific array of dietary supplements, including inosine, various forms of vitamin E (tocopherols and tocotrienols), coenzyme Q10, niacinamide, vitamin C, N-acetyl cysteine, and a complete multivitamin. The rationale behind this combination is to leverage the anti-inflammatory and neuroprotective properties of minocycline alongside the antioxidant and metabolic support provided by the supplements to improve clinical outcomes in retinal vascular diseases. Several components are administered in sustained-release formulations to maintain consistent therapeutic levels.
- Other names
- Supplements and Minocycline for DME and NAMDSAINTS
02
Targets
MMP12 (Macrophage Metalloelastase)GSH (Glutathione)NAD (Nicotinamide adenine dinucleotide)
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